That's a good point. Sometimes it for sure does. I've had to sew up a few pelts because of it over the years. Other times it just caused internal damage and wasn't bad at all. That's mostly on coyotes running straight away and the bullet hit high and tore open the back of the coyote. Other times I've hit them right in the back of the head when the shot went high.Personally I get quite frustrated and beat myself up anytime I don't make a good shot on a coyote and when I say good shot I mean center chest. Only thing that frustrates me more than missing a coyote is gut shooting it and making a huge mess that requires follow ups.
With that in mind I will quite freely take the longer shot over the runner. My experience seeing running shots in person and in videos is they are seldom perfect and often make a mess.
Running where I had a broadside shot I can't recall hitting a coyote in the guts luckily. Upper portion of the body (heart or lungs) and no second shot was needed. On a running straight away shot I can think of 5 instances where a second shot wasn't needed. Five out of I couldn't really say how many honesty. Enough that I've learned to have another round in the chamber as quickly as possible and the crosshairs back on the coyote. If it's still moving, shoot once more.
It's funny how you remember certain things or I seem to. My buddy shot one with a 58 grain Superformance out of a .243. It looked virtually unscathed except you could hear sloshing inside of it like it was full of water.
The second was one my Uncle killed with a 6.5x284. It went through the hind end and came out of its chest.
The 3rd one my Grandpa shot offhand at a pretty good distance with a .223 using 55 grain softpoints. The bullet hit it in the hip and ended up.....not sure where. It hit something that shut it down is all I know.
The 4th one was one I had coming in and it winded me. I barked several times and it paid no attention to that. It was still within 100 yards so I shot it in the butt. The coyote fell, spun and took off again. Made it maybe 30 yards and ran straight into a yucca plant and died. I shot another one years later that came in right behind a white-tailed doe of all things. I can't recall if I missed and it headed up the hill or what. But I shot it in the butt and it didn't require another shot either. Both of those I shot with a Hornady 52 grain BTHP out of a .223 with a 16 1/2" barrel.
If one is running straight away I pretty much count on having to shoot it again. I'm just trying to stop it before it gets out there too far. One shot kills at that angle are rare in my experience. But it all depends what you're shooting whether it be cartridge or bullet wise. If you're shooting a 6.5x284 or something similar it'll most likely be okay as far as killing on the first shot goes.