The first year I started using an Ar15 on called coyotes I used hornady superformance with 53 grain vmax. I don't recall actually losing a coyote with them but they did show a clear lack of getting the job done even at 223 speeds. This was shown by splashes and finishing shots needed. too many people say oh you're crazy I killed coyote with them and they worked great. Then you find the truth is they shot like 2 coyotes and both died. I really want to see about 25 kills before I render a final verdict on a bullet cartridge combination.
vmaxes are built with the thinnest jackets of the main line bullets I know of. Noslers btips have a chunk of copper in the back, they are generally great bullets if you get them to shoot for coyote. Sierra at least in 22 caliber has the thickest jackets of the bunch.
the 53's do offer a BC/performance advantage. once you get beyond about 100 yards they are going to hold speed longer than 50's and thus will be flatter and hit harder on varmints.
