From the St. Louis area I would be scouting out 44 Hwy or 70 Hwy and on out toward the large lake complexes in mid-state, or Fort Leonard Wood or due north toward Mark Twain Lake. There is a heck of a lot of game of all sorts in those fertile rolling farmlands. Deer, turkey, rabbit, quail, farm livestock and fowl coupled with more diverse cover and topography (read: predator smorgasbord) make those areas much better hunting than the large expanses of steep and rough timbered Mark Twain National Forest down south. Easier hunting, more critters, and people willing to offer access for predator removal along with a good amount of public ground make it an easy choice of areas to look toward.