What would be your choice and why. For lots of rounds down range for a varmint gun. Bolt action 18" is preferred. Also twist rates, stay with a 1-8 or go to a 12 twist?
243
243 ai
6xc
6gt
6x47L
I'll assume you have a 308 bolt face to work with, so.....
I believe it's best to pick a bullet and/or weight you want to shoot, at the velocity you would like to shoot them at, then pick the cartridge that will do that at sane pressures.
First choice would be a 6BR. Great accuracy, good velocity, with decent barrel life.
6GT might be 2nd choice, as you have a 22 in the works. If you use bushing dies, just switching to the appropriate bushing size would be the easy button.
I wouldn't go bigger than the GT, in fact my choice for a 6mm prairie dog cartridge is the 6 Dasher. I have them in fast & slow twists.
I'm a huge 6x47 Lapua fan, & have several of those too, but not for high volume endeavors.
Bullet & twist would be determined from max yardage you're anticipating.
I never subscribe to the notion to just get a fast twist, as it'll shoot everything just fine....maybe, maybe not.
Max accuracy generally come from matching the twist to the bullet.