I have killed coyotes with cartridges from 17 HMR to 30-06. Now days I generally use a 223 AR15. I love the 22-250 and 243 but generally don't like the loudness of those cartridges. I have had runners with the 243 and smaller cartridges, probably because poor shot placement, LOL.
Basically IMO the 223 is adequate for most called coyotes at reasonable distance with proper shot placement and a good bullet. I would add, the 22-250 is prolly one of my favorite coyote cartridges. On a side note I killed a bunch with my old Sako 243, but now I am building an AR10 in 243, other than it weighing like a pig, I plan on getting a few with it and the 75 vmax.
