Guess it depends on the style of hunting you are doing and terrain you are hunting.
Spot and stalk in mountainous terrain where shots could be cross canyon, I'd want a lot more gun than if I was still hunting or even calling where shots will be relatively short.
Of course, shot placement is key regardless. Personally, I want enough horsepower and penitration to break shoulder bones and ideally exit the opposite side. 2 bleeders is better than 1 and that fur can soak up a lot of blood.
Just my opinion from my limited experience.