I shot hundreds of coyotes with the 60g Sierra with win 760 when we were hunting in Mexico, and it is the best fur friendly commercial bullet we found for a 243, also the bullet is on the tougher side. You can take coyotes with this bullet quartering shots coming and going. This is a VERY accurate bullet in my 6ppc's and 6 BR's also.
In the early 90's, the ballistician for Sierra told me that it was the most accurate bullet that Sierra made. I was showing him the groups that I had shot with a Benchrest rifle shot with 60g Bergers and 60g Sierra's and told him that if they closed the point up more, the bullet would compete with the Berger 60's on the BR market, same for the Berger 75's.
We never got runners and spinners with the 243 with the 60g Sierra. In fact, on one coyote that was out about 400 yards, I underestimated the yardage. He was standing broadside, I held high on the shoulder, but the bullet impact was low and broke both of his front legs in one shot. That coyote would plow the ground with his nose till he got up on his hind legs, then started hopping off till he lost his balance. ON his third hopping session, I hit him dead center, and he was instantly dead.
I found that in the 243, that when the coyote was hit behind the diaphragm, that the coyote was dead right there on the spot. After having a dozen coyotes get up and walk off after being hit behind the diaphragm with a 22/250, I went to the 243 and 6mm Rem with the 60g Sierra. I used 760 in all these guns with a fed 210 primer.
My pard shot a 270 win(90g Sierra HP) and another pard shot a 25/06(100g Speer HP), and they blew tremendous holes in coyotes. Later on, in my 243's and 6 Rem's, I went to the Sierra 80g Single shot pistol bullet to get my "big hole" loads on coyotes.
Later on, I started making benchrest bullets for myself only. I played around with the size of the HP and found a HP size that worked well on coyotes with a 65g bullet that did not penetrate. Berger MEF 65g was close in duplicating my HP size if you can find any.